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137948

Comparative Study between Intrathecal Morphine and Nalbuphine Added to Hyperbaric Bupivacaine 0.5% in Elective Cesarean Delivery

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Last updated: 03 Jan 2025

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Abstract

Background: Many additives have been used to improve spinal anesthesia; morphine and nalbuphine are commonly used drugs.
Objective: This work aimed to compare intrathecal morphine and different doses of nalbuphine in elective cesarean section (CS).
Patients and Methods: This double-blinded, randomized controlled study was done on 150 patients, American Society of Anesthesiologist (ASA) grade I to II undergoing elective CS. Patients underwent spinal anesthesia 3 ml with 10 mg hyperbaric bupivacaine 0.5 % with the addition of a 1 ml volume (morphine or nalbuphine) according to the group; Group M: 150 μg morphine, Group N1: 1 mg nalbuphine, and Group N2: 2 mg nalbuphine.
Results: Intraoperative and postoperative hemodynamics, respiratory rate, SPO2 and Apgar score were insignificantly different in all groups. Postoperative VAS was significantly decreased in group M and was insignificantly different between group N1 and group N2. Postoperative BROMAGE was significantly higher in group M. Time of rescue analgesia was significantly increased in group M and was insignificantly different between group N1 and group N2. Postoperative nausea and vomiting (PONV) was insignificantly different in all groups, and pruritus was significantly decreased in group N1.
Conclusions: As additives to hyperbaric bupivacaine in the spinal block, morphine was superior to nalbuphine in decreasing VAS and increased time for rescue analgesia by prolonged sensory block. Increasing the dose of nalbuphine up to 2 mg did not increase the analgesic effect. Nalbuphine is superior to morphine in decreasing pruritus, and both drugs have similar effects on neonatal APGAR score and hemodynamics

DOI

10.21608/ejhm.2021.137948

Keywords

morphine, nalbuphine, Cesarean delivery

Authors

First Name

Khaled Mohammed

Last Name

Hassan

MiddleName

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Affiliation

Department of Anaesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

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Orcid

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First Name

Hamza Aboalam

Last Name

Mahmood

MiddleName

-

Affiliation

Department of Anaesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

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Orcid

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First Name

Islam Khaled

Last Name

Moustafa

MiddleName

-

Affiliation

Department of Anaesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

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City

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Orcid

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First Name

Ghada Abd el-Gaber

Last Name

Rezk

MiddleName

-

Affiliation

Department of Anaesthesia, Intensive Care and Pain Management, Faculty of Medicine, Sohag University, Egypt

Email

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City

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Orcid

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Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-10

Publish Date

2021-01-01

Page Start

80

Page End

88

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 80-88.pdf

PDF . 532.2kB

Link

https://ejhm.journals.ekb.eg/article_137948.html

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https://ejhm.journals.ekb.eg/service?article_code=137948

Order

15

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Comparative Study between Intrathecal Morphine and Nalbuphine Added to Hyperbaric Bupivacaine 0.5% in Elective Cesarean Delivery

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Type

Article

Created At

22 Jan 2023