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137140

Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section

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Last updated: 03 Jan 2025

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Abstract

Background: Primary postpartum hemorrhage (PPH) plays a major role in maternal mortality and morbidity like severe anemia, blood transfusion requirement, hospital stay and infection. Tranexamic acid is now recommended in treatment of PPH, yet its prophylactic use before delivery is still not recommended.
Objective: To assess the efficacy of preoperative administration of Tranexamic acid in decreasing blood loss during elective cesarean section.
Patients and Methods: The study was conducted at Department of Obstetrics and Gynecology of Menoufia University Hospitals. It included 100 pregnant females who went through elective cesarean section with age >18 and < 35 years and singleton alive fetus. They were randomly allocated to two groups: the study group of which women received 1 gm of tranexamic acid 20 minutes before skin incision and the control group who did not receive tranexamic acid. The assessment included the following: measurement of blood loss amount and estimation of postoperative 1st day hemoglobin and hematocrit value.
Results: There was highly statistically significant difference between both groups regarding the amount of blood loss during cesarean delivery and blood loss 2 hours from end of CS (p ≤ 0.001). This was reflected in the percentage of difference of preoperative and postoperative hemoglobin and hematocrit values, which showed highly significant statistical difference (p ≤ 0.001).
Conclusion: Tranexamic acid administration before elective cesarean section was effective in decreasing intraoperative and postoperative bleeding. And in turn reduces the incidence of PPH with no immediate maternal or neonatal side effects.

DOI

10.21608/ejhm.2021.137140

Keywords

cesarean section, Postpartum Hemorrhage, Tranexamic acid

Authors

First Name

Ayman A.

Last Name

Soliman

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

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City

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Orcid

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First Name

Sayed A.

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Ragab M.

Last Name

Dawood

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

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City

-

Orcid

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First Name

Aliaa A.

Last Name

Fayed

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

aliaafayed3@gmail.com

City

-

Orcid

-

First Name

Amira A.

Last Name

Fathey

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

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Volume

82

Article Issue

1

Related Issue

20276

Issue Date

2021-01-01

Receive Date

2021-01-08

Publish Date

2021-01-01

Page Start

6

Page End

10

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 82_Issue 1_Pages 6-10.pdf

PDF . 442.1kB

Link

https://ejhm.journals.ekb.eg/article_137140.html

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https://ejhm.journals.ekb.eg/service?article_code=137140

Order

2

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Prophylactic Use of Tranexamic Acid in Reducing Blood Loss during Elective Cesarean Section

Details

Type

Article

Created At

22 Jan 2023