Beta
ManageSearchChatDiscover
133964

Letrozole Therapy versus Extended Clomiphene Citrate Therapy for Induction of Ovulation in Resistant Patients with Polycystic Ovarian Syndrome in Low Resource Communities

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: many drugs can be used in ovulation induction in patients with clomiphene-resistant polycystic ovarian syndrome (PCOs).
Objective: to evaluate the effect of letrozole therapy versus extended clomiphene citrate therapy for ovulation induction in clomiphene-resistant polycystic ovarian syndrome patients
Patients and Methods: The study included 100 infertile patients who had failed induction by clomiphene for three cycles. They were randomly allocated to receive either letrozole or extended clomiphene therapy. The effects of these drugs on follicular volume, ovulation, endometrium thickness and occurrence of pregnancy were evaluated. Results: No significant difference was found between both groups regarding age, body mass index, basal FSH level, LH level, prolactin level, thyroid function and semen analysis of the husband. Use of letrozole or extended clomiphene led to improvement of number of growing follicles, ovulation rate and pregnancy rate after 3 cycles of ovulation induction.
Conclusion: The results of this study revealed that use of letrozole or extended treatment with clomiphene did not show better outcomes over each other in number of growing follicles, ovulation rates, occurrence of pregnancy and pregnancy outcomes. Letrozole group showed a significant increase in the endometrium thickness than extended clomiphene group but this did not affect pregnancy rate.

DOI

10.21608/ejhm.2020.133964

Keywords

Letrozole, extend clomiphene therapy, PCOs, clomiphene resistance

Authors

First Name

Mohamed A.

Last Name

Emara

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Dalia I.

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed A. M.

Last Name

Hassanein

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology at Sohag General Hospital, Sohag, Egypt

Email

mamhassanein@yahoo.com

City

-

Orcid

-

First Name

Amira A.

Last Name

Fathey

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

Volume

81

Article Issue

7

Related Issue

19561

Issue Date

2020-10-01

Receive Date

2020-12-30

Publish Date

2020-10-01

Page Start

2,456

Page End

2,461

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 7_Pages 2456-2461.pdf

PDF . 385.5kB

Link

https://ejhm.journals.ekb.eg/article_133964.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=133964

Order

27

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Letrozole Therapy versus Extended Clomiphene Citrate Therapy for Induction of Ovulation in Resistant Patients with Polycystic Ovarian Syndrome in Low Resource Communities

Details

Type

Article

Created At

22 Jan 2023