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133961

Hepato-nephro-toxicity Induced by Premium Fungicide and Protective Effect of Sesame Oil

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Last updated: 03 Jan 2025

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Abstract

Background: Fungicides impact on agriculture is reflected by the wide spread use of azoxustrobin (AZX) and metalxyl M, the active ingredients of premium fungicide used on more than 80 different crops.
Objective: The present study aimed to investigate the hepato-renal-toxicity of premium fungicide on adult albino rats and focused on benefits of sesame oil in detoxification of toxicological effects of fungicides.
Materials and methods: Thirty male albino rats allocated into five groups, -ve, +ve control and sesame oil groups. While the two other groups were treated with sesame oil before and after fungicide exposure daily by gavage for (28 days). Results: Exposure of male albino rats to Azoxystrobin fungicide resulted in liver and kidney injury as evidenced by increased liver and renal function bioindicator (ALT, AST, ALP, urea and creatinine)..Also, glutathione (GSH) was significantly decreases and malondialdhyde (MDA) was increased as oxidative stress biomarkers. In addition, degeneration of some tubular epithelial cells and hemorrhage in kidney and severe inflammatory cell infiltration in liver. Conclusion: The present study concluded that premium had induced functional and histological changes in liver and kidney male rats. Sesame oil successfully ameliorated the oxidative stress, hepatotoxicity and nephrotoxicity of fungicide.

DOI

10.21608/ejhm.2020.133961

Keywords

liver function, renal function, Oxidative Stress, Sesame oil, Azoxystrobin, Metalxyl

Authors

First Name

Reem M.

Last Name

Ziada

MiddleName

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Affiliation

Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab. (CAPL), Agricultural Research Center, Ministry of Agriculture, Dokki, Giza 12618, Egypt

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Orcid

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First Name

Sanaa M.

Last Name

Abdulrhman

MiddleName

-

Affiliation

Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab. (CAPL), Agricultural Research Center, Ministry of Agriculture, Dokki, Giza 12618, Egypt

Email

-

City

-

Orcid

-

First Name

A.A.

Last Name

Nahas

MiddleName

-

Affiliation

Mammalian and Aquatic Toxicology Department, Central Agricultural Pesticides Lab. (CAPL), Agricultural Research Center, Ministry of Agriculture, Dokki, Giza 12618, Egypt

Email

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City

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Orcid

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Volume

81

Article Issue

7

Related Issue

19561

Issue Date

2020-10-01

Receive Date

2020-12-30

Publish Date

2020-10-01

Page Start

2,445

Page End

2,450

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 7_Pages 2445-2450.pdf

PDF . 279.5kB

Link

https://ejhm.journals.ekb.eg/article_133961.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=133961

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Hepato-nephro-toxicity Induced by Premium Fungicide and Protective Effect of Sesame Oil

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Article

Created At

22 Jan 2023