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Background: In endometriosis, there is a chronic immune and inflammatory reaction.
Objective: To study the PCR genetic expression of interleukin 37 in the eutopic and ectopic endometrium of women with endometriosis in comparison with controls.
Patient and Methods: Forty-six patients were included in the study. Twenty-three women diagnosed as endometriosis and twenty-three women diagnosed as free of endometriosis were subjected to laparoscopy for any other gynecological cause. Interleukin 37 gene expression was studied in ectopic and eutopic endometrium using polymerase chain reaction.
Results: Ectopic endometrium expressed high levels of mRNA compared to eutopic endometrium in endometriosis patients. Eutopic endometrium of endometriosis patients expressed high levels of mRNA compared to eutopic endometrium of controls.
Conclusion: The finding of high mRNA produced in endometrial tissue suggests that interleukin 37 may be important in the chronic inflammation occurring during endometriosis.
DOI
10.21608/ejhm.2020.132889
Keywords
Endometriosis, PCR Genetic Expression, Interleukin 37
Authors
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Ihab Fouad Serag Eldin
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https://ejhm.journals.ekb.eg/article_132889.html
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https://ejhm.journals.ekb.eg/service?article_code=132889
Publication Title
The Egyptian Journal of Hospital Medicine
Publication Link
https://ejhm.journals.ekb.eg/
MainTitle
PCR Genetic Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Women with Endometriosis