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132886

The Connection between Serum Level of Paraoxonase (PON 1) and Atherogenesis in Egyptian Patients with Type II Diabetes Mellitus

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Last updated: 24 Dec 2024

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Abstract

Background: Diabetes is considered a health problem all around the world that affects people at different age levels with increasing incidence and spread of disease leading to many complications. Paraoxonase is known as an anti- oxidant enzyme, it was originally found to stimulate the hydrolysis of paraoxonase and has a wide range of important analytical activities.
Objective: To evaluate the serum level of paraoxonase1 (PON 1) in patients with type 2 diabetes mellitus with or without hypertension as a predictor marker of atherogenesis.
Patients and methods: This study was a case-control study and carried out on 90 persons (45 males, 45 females) they were selected from the outpatient and inpatient clinic of Qena University Hospital. The study was conducted during the period between October 2019 and March 2020.
Results: There was an increase in the level of blood glucose, serum cholesterol, serum triglycerides, serum LDL, serum Hs CRP, decreased serum PON 1, and serum HDL in (diabetic group) as compared to (healthy individuals group). The study also showed a positive correlation between the decreased level of serum PON 1 in patients and decreased serum HDL. The study also showed a negative correlation between the decreased level of serum PON 1 and increased serum glucose serum cholesterol, serum triglycerides, serum LDL, and serum Hs CRP. Also, measurement of serum PON 1 may become a useful, expanding tool for evaluating atherogenesis diabetes and hypertension. Conclusion: Therefore, measurement of the proportion of serum PON 1 as a biomarker of atherogenesis in Egyptian patients with type 2 diabetes mellitus.

DOI

10.21608/ejhm.2020.132886

Keywords

Paraoxonase (PON 1), Atherogenesis, type II diabetes mellitus

Authors

First Name

EL-Saeed Mostafa El-Saeed

Last Name

Elbawab

MiddleName

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Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

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First Name

Sameh Salah-El-din El-Saed

Last Name

Mohamed

MiddleName

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Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

Email

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City

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Orcid

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First Name

Ahmed Essa

Last Name

Fahmy

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

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Volume

81

Article Issue

7

Related Issue

19561

Issue Date

2020-10-01

Receive Date

2020-12-27

Publish Date

2020-10-01

Page Start

2,400

Page End

2,404

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 7_Pages 2400-2404.pdf

PDF . 424.4kB

Link

https://ejhm.journals.ekb.eg/article_132886.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=132886

Order

17

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Connection between Serum Level of Paraoxonase (PON 1) and Atherogenesis in Egyptian Patients with Type II Diabetes Mellitus

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Article

Created At

22 Jan 2023