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132882

Study of the Role of Adiponectin Gene Polymorphism in Patients with Thyroid Disorders

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Last updated: 03 Jan 2025

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Abstract

Background: Both hypo & hyperthyroidism are associated with some morbidity & mortality. Adiponectin is a fat cell-derived hormone that protect against atherosclerotic cardiovascular diseases through its enhancing effect on insulin sensitivity. Clinical studies investigating serum adiponectin levels in patients with hypothyroidism and hyperthyroidism have reported conflicting results.
Objective: The study aimed to study the role of adiponectin gene polymorphism in patients with thyroid disorders either hypothyroidism or hyperthyroidism. Also, the relation of adiponectin gene polymorphism with obesity and DM.
Patients and Methods: Cross sectional study was conducted on one hundred and fifty cases that were classified into hypothyroid group and hyperthyroid group. History, examination and investigation (adiponectin gene) was done.
Results: In current study within hypothyroid & hyperthyroid group, there was non-significant relation between gene polymorphism and either total T3, free T3, free T4 or TSH. There was statistically non-significant relation between associated diabetes and either gene or allele polymorphism among patients within hypothyroid group and hyperthyroid group. There was statistically non-significant relation between patient BMI and either gene or allele polymorphism among patients within hypothyroid group and hyperthyroid group.
Conclusion: There was no role of adiponectin gene polymorphism and either total T3, free T3, free T4 or TSH. In addition, there was no role of adiponectin gene polymorphism and either obesity and DM.

DOI

10.21608/ejhm.2020.132882

Keywords

Total T3, Free T3, T4, TSH, adiponectin, Polymorphism

Authors

First Name

Mohammed Almhdy Gamal Aldein

Last Name

Kamar

MiddleName

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Affiliation

Department of Internal Medicine, Faculty of Medicine – Zagazig University.

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Orcid

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First Name

Mohammed Mohammed

Last Name

Awad

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine – Zagazig University.

Email

-

City

-

Orcid

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First Name

Mayada Mohammed

Last Name

Mousa

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine – Zagazig University.

Email

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City

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Orcid

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First Name

Shimaa Mohammed

Last Name

Ragab

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine – Zagazig University.

Email

dr.shimaa1984@yahoo.com

City

-

Orcid

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Volume

81

Article Issue

7

Related Issue

19561

Issue Date

2020-10-01

Receive Date

2020-12-27

Publish Date

2020-10-01

Page Start

2,383

Page End

2,388

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 7_Pages 2383-2388.pdf

PDF . 461.7kB

Link

https://ejhm.journals.ekb.eg/article_132882.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=132882

Order

14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study of the Role of Adiponectin Gene Polymorphism in Patients with Thyroid Disorders

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Article

Created At

22 Jan 2023