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131249

Study of CD4 and CD8 Subsets in Morbid Obese Population

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Last updated: 03 Jan 2025

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Abstract

Background: Immune dysfunction is one of the co-morbidities that became well recognized several years ago in people with obesity. Objective. To study the peripheral blood T-cell compartment, the absolute counts and relative frequencies of T-cell subpopulations including CD8+T cells; CD4+Tcells in adults suffering morbid obesity compared to lean subjects. Patients and methods: This case-control study included 30 adults with morbid obesity and 20 lean healthy subjects who were age and sex-matched.CD4 and CD8 absolute and relative count together with CD4/CD8 ratio were assessed and compared between the two groups. Results: Adults with morbid obesity had higher total leucocyte count (TLC), CD4 percentage, CD4 absolute count, and CD4/CD8 ratio than that of controls. On the other hand, the CD8 percentage was lower in people with morbid obesity. There were positive correlations between CD4% and BMI, waist circumference, cholesterol, triglyceride, LDL, and TLC and neutrophils count. There was a negative correlation between the percentage of CD8 and BMI. CD4/CD8 ratio correlated positively with BMI but negatively with systolic blood pressure. Conclusion: CD4+ CD8+ T lymphocytes assay could help assess the immune state and recognize obese at risk of immune dysfunction complication as infection and metabolic diseases.

DOI

10.21608/ejhm.2020.131249

Keywords

CD4, CD8, morbid, Obesity, lymphocytes

Authors

First Name

Fawzia Hassan Abo

Last Name

Ali

MiddleName

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Affiliation

Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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First Name

Asmaa Saber Mostafa

Last Name

Abdel Rehim

MiddleName

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Affiliation

Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

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Orcid

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First Name

Hoda Mohamed

Last Name

El Sayed

MiddleName

-

Affiliation

Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

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Orcid

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First Name

Shaimaa Hani

Last Name

Fouad

MiddleName

-

Affiliation

Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

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City

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Orcid

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First Name

Amira Ramadan

Last Name

Elmahdi

MiddleName

-

Affiliation

Department of Internal Medicine, Allergy & Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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Orcid

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Volume

81

Article Issue

7

Related Issue

19561

Issue Date

2020-10-01

Receive Date

2020-12-20

Publish Date

2020-10-01

Page Start

2,310

Page End

2,317

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 7_Pages 2310-2317.pdf

PDF . 582.7kB

Link

https://ejhm.journals.ekb.eg/article_131249.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=131249

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study of CD4 and CD8 Subsets in Morbid Obese Population

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Article

Created At

22 Jan 2023