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131140

Serum leptin level in diabetic patients with erectile dysfunction

Article

Last updated: 03 Jan 2025

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Abstract

Background: Erectile dysfunction (ED) is a common sexual problem affecting men. Diabetes mellitus (DM) is one of the most common comorbidities of ED. Leptin is a 167-amino-acid peptide that is mainly expressed in white adipose tissue but is also found in a variety of tissues. Objective: To estimate serum level of leptin in diabetic patients with ED and correlate level of serum leptin in diabetic patients with severity and origin of ED. Patients and methods: Cross-sectional descriptive study was conducted on 64 individual male; 34 diabetic patients of both types of DM with ED and 30 non diabetic normal erectile function as control. All patients were evaluated clinically by history included IIEF-5 score and examination. Assessment of serum leptin level, HbA1c, cholesterol, triglycerides was done and penile duplex study was done only for diseased patients. Results: Serum leptin significantly increased in cases than control (P <0.001). Also, there was increased in diabetic men vasculogenic ED either arterial, venous or mixed (P =0.047). Serum leptin was correlated with the severity of ED (P =0.046). Conclusion: Leptin may play an important biomarker as a cost-effective method for diagnosis and assessment of severity of vasculogenic ED in DM and as a good predictor for ED occurrence.

DOI

10.21608/ejhm.2020.131140

Keywords

Diabetes mellitus, Erectile dysfunction, Serum leptin

Authors

First Name

Moustafa A.

Last Name

El Taieb

MiddleName

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Affiliation

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Email

moustafa.eltaib@aswu.edu.eg

City

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Orcid

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First Name

Eisa M.

Last Name

Hegazy

MiddleName

-

Affiliation

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Email

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City

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Orcid

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First Name

Ahmed I.

Last Name

Ebeed

MiddleName

-

Affiliation

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Email

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City

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Orcid

-

First Name

Mostafa A.

Last Name

Maher

MiddleName

-

Affiliation

-

Email

-

City

-

Orcid

-

Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-19

Publish Date

2020-10-01

Page Start

2,295

Page End

2,299

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 6_Pages 2295-2299.pdf

PDF . 283.4kB

Link

https://ejhm.journals.ekb.eg/article_131140.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=131140

Order

30

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serum leptin level in diabetic patients with erectile dysfunction

Details

Type

Article

Created At

22 Jan 2023