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131134

Risk Factors of Type 1 Diabetes Mellitus in Children Attending Aswan University Hospital

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Last updated: 03 Jan 2025

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Abstract

Background: Type 1 diabetes (T1DM) is a chronic disease caused by immune-mediated destruction of insulin producing beta cells in the pancreas. The destruction of beta cells results in insulin insufficiency, and patients develop life-threatening hyperglycemia that clinically manifests with weight loss, polyuria, and polydipsia. Objective: This study aimed to search for disease prediction and disease prevention.
Patients and methods: The present cross-sectional study was conducted at Aswan University Hospital. One hundred children with T1DM were included during the period from April to November 2018. The mean age of the included patients was 7.2 ± 4.3 years and the age at onset of the disease was 4.56 ± 2.9 years. 56% of the patients were males.
Results: In our cohort, we found that, in terms of obstetric history, 76% of the mothers delivered by CS and 12% of them had history of preeclampsia. 13% had a history of gestational diabetes. On the other hand, 13% and 29% of the mothers had a history of infectious diseases and use of antibiotics, respectively. There were no statistically significant associations between age group and preeclampsia (p =0.33), gestational diabetes and use of insulin (p =0.67), infectious diseases (p =0.91), use of antibiotic (p =0.26), use of antihypertensives (p =0.22), and mode of delivery (p =0.067).
Conclusion: In conclusion, Egyptian children with T1DM had wide range of genetics, environmental, maternal, and neonatal risk factors that may have contributed to the development of T1DM.

DOI

10.21608/ejhm.2020.131134

Keywords

type 1 diabetes mellitus, children, Aswan University Hospital

Authors

First Name

Asmaa Mohammed

Last Name

Ismail

MiddleName

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Affiliation

Department of Pediatrics, Faculty of Medicine, Aswan University

Email

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City

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Orcid

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First Name

Ahmed El-Meshwady Ahmed

Last Name

Mohammed

MiddleName

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Affiliation

Department of Pediatrics, Faculty of Medicine, Aswan University

Email

ahmed.elmeshwady1992@gmail.com

City

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Orcid

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First Name

Hanan Mohammed

Last Name

Abd El-Moneim

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Aswan University

Email

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City

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Orcid

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Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-19

Publish Date

2020-10-01

Page Start

2,265

Page End

2,273

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_131134.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=131134

Order

26

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Risk Factors of Type 1 Diabetes Mellitus in Children Attending Aswan University Hospital

Details

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Article

Created At

22 Jan 2023