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131124

Plasma and Urinary Calprotectin Levels in Type 2 Diabetic Patients with Peripheral Arterial Disease

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Last updated: 30 Jan 2023

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Abstract

Background: Plasma calprotectin is a persistent biomarker of insulin resistance (IR), gastroenteritis, and cardiovascular disease (CVD). We assessed the role of plasma and urinary calprotectin in type 2 diabetes patients with peripheral arterial disease (PAD), to assess whether calprotectin is a risk factor for developing PAD in type 2 diabetes patients.
Aim of the work: To study the association of plasma and urinary calprotectin levels with peripheral arterial disease in type 2 diabetic patients
Methods: The current study was conducted on 90 subjects. They were subdivided into 3 groups. Group I: 30 type 2 diabetics with PAD, group II: 30 type 2 diabetics without PAD and group III: 30 healthy control subjects of comparable age and sex. They were subjected to history taking, full clinical examination, anthropometric measurement, plasma and urinary calprotectin levels that were measured by ELISA and ankle brachial index. In addition, HbA1c, fasting serum lipid profile, highly sensitive CRP and CBC were measured.
Results: plasma calprotectin level was significantly higher in patients with T2DM with lower extremity peripheral arterial disease (LEPAD) compared to the other 2 groups, urinary calprotectin was significantly higher in all type 2 diabetic subjects compared to healthy control group. Age, current smoking status, duration of diabetes, glycated hemoglobin and plasma calprotectin were independent determinant of peripheral arterial disease in T2DM patients
Conclusion: Elevated plasma and urinary calprotectin levels in diabetic patients compared to healthy control suggest the possible role of calprotectin in development of atherosclerosis and peripheral arterial disease and the possibility of its use as a biomarker for diabetic vasculopathy.

DOI

10.21608/ejhm.2020.131124

Keywords

Plasma and urinary calprotectin, Type 2 diabetes mellitus, Peripheral Arterial Disease

Authors

First Name

Halawa

Last Name

M

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Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine – Ain Shams University, Cairo, Egypt

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Orcid

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First Name

Abushady

Last Name

MM

MiddleName

-

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine – Ain Shams University, Cairo, Egypt

Email

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City

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Orcid

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First Name

Abdelsalam Besibes

Last Name

MM

MiddleName

-

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine – Ain Shams University, Cairo, Egypt

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City

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Orcid

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First Name

Basabbea

Last Name

AS

MiddleName

-

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine – Ain Shams University, Cairo, Egypt

Email

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City

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Orcid

-

First Name

Mohamed

Last Name

NR

MiddleName

-

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine – Ain Shams University, Cairo, Egypt

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Orcid

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Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-19

Publish Date

2020-10-01

Page Start

2,222

Page End

2,226

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 6_Pages 2222-2226.pdf

PDF . 371.4kB

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https://ejhm.journals.ekb.eg/article_131124.html

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https://ejhm.journals.ekb.eg/service?article_code=131124

Order

20

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023