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131123

Serum Fibroblast Growth Factor 19 As A Predictor and Follow Up of Hepatocellular Carcinoma

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Last updated: 03 Jan 2025

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Abstract

Background: Abnormal autocrine fibroblast growth factor 19 (FGF19) productions have been observed in several types of cancers, including hepatocellular carcinoma (HCC), which is considered 3rd cause of cancer deaths worldwide with gradually increased incidence. Objective: To investigate the role of FGF 19 in prediction, diagnosis and follow up of HCC together with alpha feto protein (αFP). Patients and methods: This study was carried in Internal Medicine Department and Clinical Pathology Department, Faculty of Medicine Zagazig University Egypt in the period from October 2017 to October 2020. The study included 150 patients (111 males and 39 females) classified into 3 groups: 50 healthy volunteers as a control, 50 patients with liver cirrhosis documented by examination and investigation and 50 Patients with HCC with variable sizes. All participants in the study were subjected for the following after written consent and approval by their search ethics committee of Zagazig University.
Result: The median of FGF19 level between control, liver cirrhosis and HCC was 4, 6 and 10 87 pg/ml respectively with higher sensitivity for detection of small HCC with high significance of α Fp between HCC > cirrhosis > control. Conclusion: FGF19 can be used successfully as a novel biomarker for HCC diagnosis and follow up after treatment together with already existing biomarker α FP.

DOI

10.21608/ejhm.2020.131123

Keywords

α FP, HCC, FGF 19

Authors

First Name

Said Abdelbaky

Last Name

Gad

MiddleName

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Affiliation

Internal Medicine Department Faculty of Medicine, Zagazig University

Email

saidabdelbaky12345@gmail.com

City

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Orcid

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First Name

Ahmed I.

Last Name

Elagrody

MiddleName

-

Affiliation

Internal Medicine Department Faculty of Medicine, Zagazig University

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City

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Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-19

Publish Date

2020-10-01

Page Start

2,217

Page End

2,221

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 6_Pages 2217-2221.pdf

PDF . 334.0kB

Link

https://ejhm.journals.ekb.eg/article_131123.html

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https://ejhm.journals.ekb.eg/service?article_code=131123

Order

19

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Serum Fibroblast Growth Factor 19 As A Predictor and Follow Up of Hepatocellular Carcinoma

Details

Type

Article

Created At

22 Jan 2023