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131122

Role of D-Dimer in Assessment of the Severity of Community Acquired Pneumonia in Children

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Last updated: 24 Dec 2024

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Abstract

Background: Pneumonia remains the leading cause of death in children under five worldwide. It accounts for about 1.6 million deaths a year in this age group - 18% of all deaths among children under five. More than 99% of all pneumonia deaths occur in low- and middle-income countries.
Objective: To detecting the role of D-dimer in assessment of the severity and prognosis of community acquired pneumonia (CAP) in children.
Patients and Methods: This was a cross sectional study carried out in Zagazig University Hospital, Pediatric, Microbiology and Immunology Departments. 143 children with pneumonia aged 6 months to 12 years old were included in the study that was conducted in the period from January 2019 to June 2019. Blood samples were taken from the antecubital vein with an injector and placed into citrated tubes. After they were centrifuged, the samples were evaluated with the quantitative ELISA method.
Results: The study showed that plasma D-dimer levels were higher in patients with lobar or multi-lobar pneumonia than in patients with segmental pneumonia. Additionally, the present study revealed a significant area under curve with cutoff > 0.85 and with sensitivity 97% and specificity 95% of D-dimer.
Conclusion: Pneumonia severity (CAP) patients showed increased plasma D-dimer levels in absence of an accompanying disease that could increase D-dimer levels.

DOI

10.21608/ejhm.2020.131122

Keywords

Pneumonia severity, D-Dimer, Community-acquired pneumonia

Authors

First Name

Hasan El-Banna

Last Name

Khedr

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Orcid

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First Name

Dina Mohamed

Last Name

Shokry

MiddleName

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Affiliation

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Email

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Orcid

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First Name

Eman Mohamed

Last Name

El Behedy

MiddleName

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Affiliation

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Email

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Orcid

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First Name

Zeinab El-Sayed Kotb

Last Name

El-Sayed

MiddleName

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Affiliation

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City

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Orcid

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Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-19

Publish Date

2020-10-01

Page Start

2,211

Page End

2,216

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 6_Pages 2211-2216.pdf

PDF . 387.8kB

Link

https://ejhm.journals.ekb.eg/article_131122.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=131122

Order

18

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of D-Dimer in Assessment of the Severity of Community Acquired Pneumonia in Children

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Article

Created At

22 Jan 2023