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127968

Effect of Chronic Stress on The Testis of The Adult Male Albino Rat and The Role of Ginger

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Last updated: 03 Jan 2025

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Abstract

Background: Infertility and its problems are one of the most vital problems that ranges from 10% to 15% among couples. Chronic variable stress (CVS) disrupts normal homeostasis of a variety of body systems and is a major cause of male infertility. Ginger is known to have anti-inflammatory and antioxidant properties via its free radical scavenging activity so it can be used in various experimental models as a protective agent against various toxicants. Objectives: The current work aimed to study the effect of chronic variable stress on the testis and the possible protective and therapeutic roles of the ginger on this effect. Materials and Methods: thirty-five adult male albino rats were divided into five groups. Group I; control, group II received ginger only, group III subjected to CVS, group IV CVS + pretreated with ginger and group V CVS + post-treated with ginger. All rats were weighted, sacrificed, blood samples collected to asses testosterone hormone, the testis was weighted to calculate gonadosomatic index and processed for light microscopic study. Paraffin sections were stained by hematoxylin and eosin stain. Immunohistochemical staining for PCNA, caspase-3 and androgen receptor were also performed. Results: CVS induced decreased gonadosomatic index, testosterone hormone level, destructive effects on the testis as decreased spermatogenic cells and sperm count, detachment of the cells, vacuolations and apoptosis. Ginger produced great improvement of these effects which was pronounced in the protected group (IV) than the treated one (V). Conclusion: CVS caused apoptotic changes in testis and ginger had ameliorating effects on these changes.

DOI

10.21608/ejhm.2020.127968

Keywords

CVS, testicular apoptosis, Ginger

Authors

First Name

Hadeer Abd El-Mohsen

Last Name

El-Naggar

MiddleName

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Affiliation

Department of Anatomy and Embryology, Anatomy Department, Menoufia University, Menoufia, Egypt

Email

hadderelnaggar@yahoo.com

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Orcid

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First Name

Fatma El-Nabawia A.

Last Name

El-Safty

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Anatomy Department, Menoufia University, Menoufia, Egypt

Email

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City

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Orcid

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First Name

Abeer E.

Last Name

El-mehi

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Anatomy Department, Menoufia University, Menoufia, Egypt

Email

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City

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Orcid

-

First Name

Ayman Abdallah

Last Name

Reafie

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Anatomy Department, Menoufia University, Menoufia, Egypt

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Orcid

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Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-06

Publish Date

2020-10-01

Page Start

2,184

Page End

2,194

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 6_Pages 2184-2194.pdf

PDF . 1.1MB

Link

https://ejhm.journals.ekb.eg/article_127968.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=127968

Order

14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Effect of Chronic Stress on The Testis of The Adult Male Albino Rat and The Role of Ginger

Details

Type

Article

Created At

22 Jan 2023