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127965

A Randomized-Trial Study of Corneal Collagen Cross-Linking (CXL) in Progressive-Keratoconus (PK)

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Last updated: 03 Jan 2025

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Abstract

Background: Keratoconus is a frequent, familiar, bilateral, non inflammatory, and gradually progressive corneal ectasia, which leads to corneal protrusion, irregular astigmatism, and decrease vision. Currently, the corneal cross-linking (CXL) treatment could attain vision improvement.
Aim: To investigate the topographic, refractive, and clinical-out-comes after six months CXL in gradually progressing keratoconic eyes.
Patients & Methods: A follow-up, randomized, controlled-trial study was used. In this study, 30eyes with progressive- keratoconus (PK) were recruited in the study. Cross-linking was done and achieved by a solution of 0.1% riboflavin mixture with 20% dextran for 15minutes before and during 30minutes time-period of ultraviolet A (UV-A) irradiation (3Mw\cm2). The obtained data were analysed using IBM SPSS software.
Results: Statistically significant improvements were noticed in Sim k (at 6months), Kmin (at 6months), spherical power (at 6momths), cylinder power (at 6momths), spherical equivalent [SE] (at 6months), uncorrected visual acuity (UCVA) (at 6months) and best corrected visual acuity [BCVA] (at 6months) in trial group (15patients) when compared with the controls.
Conclusions: At 6months, hopeful, promising improvements were reported in Kmax, UCVA, and BCVA. So, long term studies are requested to survey the efficiency of CXL as well as the safety of the repeated procedures.

DOI

10.21608/ejhm.2020.127965

Keywords

Corneal Collagen cross-linking, Riboflavin, Epithelium-off procedure, Topographics changes, Keratoconus

Authors

First Name

Hassan Shamselden

Last Name

Yousef

MiddleName

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Affiliation

Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt

Email

hassanetal@yahoo.com

City

-

Orcid

-

Volume

81

Article Issue

6

Related Issue

19068

Issue Date

2020-10-01

Receive Date

2020-12-06

Publish Date

2020-10-01

Page Start

2,179

Page End

2,183

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 6_Pages 2179-2183.pdf

PDF . 408.3kB

Link

https://ejhm.journals.ekb.eg/article_127965.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=127965

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13

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

A Randomized-Trial Study of Corneal Collagen Cross-Linking (CXL) in Progressive-Keratoconus (PK)

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Type

Article

Created At

22 Jan 2023