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126407

Study of The Effect of Nutrition and Glycemic Control and on IGF-1 and Growth in Pre-pubertal Egyptian Children with T1DM

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Last updated: 24 Dec 2024

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Abstract

Background: Pre-Pubertal children who have T1DM are shorter than their non-diabetic peers. Objective: In the current study we aimed to evaluate the role of HbA1c and IGF-1 in these cases. Patients and Methods: The present study was a cross-sectional study conducted on 80 pre-pubertal Egyptian children: 30 males, 30 females with T1DM and 20 age-matched controls (10 males and 10 females), the participants were recruited from the Outpatient Clinic of the Pediatric Department of Ain Shams University Hospitals and the National Institute of Diabetes and Endocrinology in Cairo, Egypt during the period from July 2018 to January 2019. Results: The height and weight percentiles were found to be lower in type 1 diabetic children when compared to the controls with median values of 14.50 (IQR 27.98) in male patients, 17.95 (IQR 29.18) in female patients, and 87 (IQR 20.58) in the controls. A negative correlation between serum IGF-1 and HbA1c as well as the height and weight percentiles were found with (P = 0.014, 0.009, and 0.05 respectively). Serum IGF-1 levels were also found to be significantly lower in patients (P <0.001) with a mean value of (77.60 ± 69.377) in male patients and (64.0 ± 29.402) in female patients and (201.0 ± 102.798) in the controls. HbA1c was also found to be negatively correlated with height percentile (P = 0.012). Conclusion: The glycemic control tested by HbA1c is an important indicator of linear growth in pre-pubertal children, Height, and weight percentiles were found to be lower in type 1 diabetic patients when compared to the healthy controls (P < 0.001) in both cases.

DOI

10.21608/ejhm.2020.126407

Keywords

T1DM, IGF-1, Growth

Authors

First Name

Raef Malak

Last Name

Botros

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First Name

Aliaa Ahmed Abdo

Last Name

El-Sherbeeny

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Orcid

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First Name

Nancy Samir

Last Name

El Barbary

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Orcid

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First Name

Ala Muhammed

Last Name

Muhammed

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First Name

Hanan Mahmoud

Last Name

Ali

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-

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Email

hanan.mahmoud29@yahoo.com

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Orcid

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Volume

81

Article Issue

5

Related Issue

18366

Issue Date

2020-10-01

Receive Date

2020-11-29

Publish Date

2020-10-01

Page Start

2,084

Page End

2,087

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_126407.html

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https://ejhm.journals.ekb.eg/service?article_code=126407

Order

27

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Study of The Effect of Nutrition and Glycemic Control and on IGF-1 and Growth in Pre-pubertal Egyptian Children with T1DM

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Article

Created At

22 Jan 2023