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The Stress Hormone Copeptin as a Prognostic Biomarker in Acute Illness

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Last updated: 03 Jan 2025

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Abstract

Background: Copeptin has been evaluated as biomarker for several illnesses such as cerebrovascular stroke, heart failure, showing a promising role mainly as a prognostic biomarker. Copeptin levels seem to be strongly related to short, mid, and long-term mortality in patients admitted to hospital showing that copeptin could be a valuable prognostic tool in the most frequent disease entities. Objective: The aim of the current study was to study the level of copeptin as a prognostic biomarker in acute illness. Patients and Methods: This study included a total of 64 patients with acute deterioration of their chronic illness as chronic liver diseases (most of them were child C on Child-Pugh score), COPD (admitted with infective exacerbation), cerebrovascular stroke and Decompensate heart failure and 20 controls, attending at emergency room, Ain Shames University Hospital. Results: Serum copeptin levels have positive correlation with longer duration of hospitalization, the higher the copeptin level the more length of hospital stay (r= 0.264* p= 0.035). There was highly statistically significant difference between copeptin level and survival rate, copeptin concentrations were significantly higher in non- survivors than in survivors (p=0.000).The mean of copeptin level among patient who died was 500 ) pmol/L with range of 70 to 750 pmol/L, while the mean of copeptin level among survivors was 60 pmol/L with range of 20-600 pmol/L.
Conclusion: It could be concluded that copeptin has a role in prognosis of mortality and morbidity of hospitalized patients and high copeptin level significantly associated with a longer hospital stay and a poor outcome of hospital admission.

DOI

10.21608/ejhm.2020.124798

Keywords

Copeptin, Acute illness, Prognostic biomarker

Authors

First Name

Raef Malak

Last Name

Botros

MiddleName

-

Affiliation

Department of Internal Medicine & Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

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City

-

Orcid

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First Name

Maram Mohamed

Last Name

Maher

MiddleName

-

Affiliation

Department of Internal Medicine & Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Rahma Khaled

Last Name

El Shaer

MiddleName

-

Affiliation

Department of Internal Medicine & Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Hanan Mahmoud

Last Name

Ali

MiddleName

-

Affiliation

Department of Internal Medicine & Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Email

hanan.mahmoud29@yahoo.com

City

Cario- Egypt

Orcid

-

Volume

81

Article Issue

5

Related Issue

18366

Issue Date

2020-10-01

Receive Date

2020-11-22

Publish Date

2020-10-01

Page Start

2,026

Page End

2,029

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 5_Pages 2026-2029.pdf

PDF . 433.1kB

Link

https://ejhm.journals.ekb.eg/article_124798.html

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https://ejhm.journals.ekb.eg/service?article_code=124798

Order

17

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Stress Hormone Copeptin as a Prognostic Biomarker in Acute Illness

Details

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Article

Created At

22 Jan 2023