Background: The definition of infertility is one year of unprotected intercourse with no pregnancy among married couples. Objective: The aim of the study is to assess the efficacy and safeness of combined hysterolaproscopy on evaluation and management of female infertility. Patients and Methods: A prospective clinical triad study was carried on 416 patients infertile women aged between 18 and 42 years with either primary or secondary infertility with normal hormone profile and without male factor infertility at the Cytogenetics and Endoscopy Unit, at Zagazig University. Those females underwent both hysteroscopy and laparoscopy through the period from August 2017 to July 2018. Results: This study showed that 42.7% of primary infertility and 59.5% of secondary infertility cases did not have any abnormality detected on laparoscopy. Endometriosis was the most common abnormality found in primary infertility followed by peritoneal adhesions, which was(12.2%) the most common abnormality found in second infertility followed by endometriosis. Abnormality in cases of primary infertility was intrauterine septum, and in secondary infertility was intrauterine synechia. Conclusions: Diagnostic hysterolaparoscopy is a very safe and effective tool for the evaluation of infertility particularly for detection of conditions like endometriosis, tubal adhesions, and intrauterine septum