Background: Ventilator weaning consists of the gradual reduction of ventilatory support and the transfer of respiratory control and the work of breathing back to the patient, resulting in discontinuation of mechanical ventilation. Objective: The aim of this study was to compare between assisted controlled (AC) ventilation mode and synchronized intermittent mandatory ventilation (SIMV) mode for easy weaning in pediatric intensive care unit (PICU). Subjects and methods: This was non-randomized control trial; 50 patients were selected and divided alternatively into two equal groups: an AC group (ACG) and an SIMV group (SIMVG). The patients were connected on SIMV or AC mode according to inclusion and exclusion criteria and follow up of the cases was done regarding ventilator settings, compliance of the patients, need of sedation, and progress of weaning process. Results: the results revealed that there wass statistically non-significant difference between the studied groups regarding progress or weaning interruption. Larger percentage within both groups had progressive uninterrupted weaning. Conclusion: We found no evidence to support any clear-cut advantage of SIMV or AC in the acute management of respiratory failure, and we concluded that AC and SIMV could improve and fasten the weaning process and increase the success rate of weaning.