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121017

Intravenous Dexamethasone Prolongs the Analgesic Effect of Caudal Bupivacaine after Hypospadias Repair Surgery

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Last updated: 30 Jan 2023

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Abstract

Background: Dexamethasone has a powerful anti-inflammatory action and has been demonstrated to reduce morbidity after surgery.
Objective: The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children.
Patients and methods: Sixty pediatric patients (aged 2-10 years) undergoing hypospadias repair surgery were included in this prospective, randomized, double-blinded study at Sohag University Hospital. After induction of general anaesthesia, children received either dexamethasone 0.5 mg ∕ kg (maximum 10 mg) (n=30) or the same volume of saline (n=30) i.v. A caudal anaesthetic block was then performed using 1 ml ∕kg of bupivacaine 0.25% in all patients.
Results: After surgery, rescue analgesic consumption, pain scores, and adverse effects were evaluated for 24 h. The time to first administration of acetaminophen (rescue analgesia) was significantly longer in the dexamethasone group (11.35 ± 2.36 hr vs 8.75 ± 1.33 hr) with a significant value of 0.01. Total amount of the analgesia required (paracetamol) was significantly lower in dexamethasone plus caudal block group than the caudal block alone (430 mg vs 680 mg) respectively.
Conclusion: Postoperative pain scores were lower in the dexamethasone group and the incidence of adverse effects was similar in both groups. Intravenous dexamethasone 0.5 mg ∕ kg in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing hypospadias repair surgery.

DOI

10.21608/ejhm.2020.121017

Keywords

dexamethasone, Bupivacaine, Hypospadias Repair Surgery

Authors

First Name

Wesam A.

Last Name

Abo Elwafa

MiddleName

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Affiliation

Department of Anaesthesia and Intensive Care, Faculty of Medicine, Sohag University

Email

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City

-

Orcid

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First Name

Amr A.

Last Name

Zakaria

MiddleName

-

Affiliation

Department of Anaesthesia and Intensive Care, Faculty of Medicine, Sohag University

Email

-

City

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Orcid

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First Name

Abdelrahman H.

Last Name

Abdelrahman

MiddleName

-

Affiliation

Department of Anaesthesia and Intensive Care, Faculty of Medicine, Sohag University

Email

-

City

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Orcid

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First Name

Wael A.

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Anaesthesia and Intensive Care, Faculty of Medicine, Sohag University

Email

-

City

-

Orcid

-

Volume

81

Article Issue

4

Related Issue

18005

Issue Date

2020-10-01

Receive Date

2020-11-01

Publish Date

2020-10-01

Page Start

1,890

Page End

1,895

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 4_Pages 1890-1895.pdf

PDF . 579.5kB

Link

https://ejhm.journals.ekb.eg/article_121017.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=121017

Order

27

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023