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121008

Histological Structure of Pancreas in Chronic Pancreatitis and The Role of Pancreatic Stellate Cells

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Last updated: 03 Jan 2025

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Abstract

Background: Chronic pancreatitis is a progressive inflammatory disease that causes damage and fibrosis of the parenchyma of pancreas, thus leads to endocrine and exocrine dysfunction.
Objective: The goals of this review were to analyze morphological alterations in pancreatic tissue during chronic pancreatitis and this analysis addresses the effect of pancreatic stellate cells (PSCs), on chronic pancreatitis, and collagen fiber deposition.
Results: This review also discussed the different immunohistochemical markers for PSCs. Alpha smooth muscle actin (α-SMA) is an excellent marker for activated PSCs. Transforming growth factor beta (TGFβ) is an important profibrogenic cytokine that appears to act by stimulating collagen production by PSCs.
Conclusion: It was concluded that chronic pancreatitis caused a significant and progressive serious effects on the acinar cells, duct system, and islets of Langerhans in the form of intracellular vacuolations, decreased zymogen granules, pyknotic nuclei and thickening of the duct wall, and extensive fibrosis. It is hypothesised that during pancreatic injury, PSCs are activated and proliferated exhibiting positive staining for the cytoskeletal protein α- SMA, and synthesising amounts of extracellular matrix proteins, particularly collagen.

DOI

10.21608/ejhm.2020.121008

Keywords

Chronic pancreatitis, pancreatic stellate cells, fibrosis

Authors

First Name

Ghada Hamed Hasan

Last Name

Romeh

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

baghdada2012@yahoo.com

City

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Orcid

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First Name

Fatma El-Nabawia Abdel-Hady

Last Name

El-Safty

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

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Orcid

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First Name

Abeer El-Said El-Mehi, Manar Ali

Last Name

Faried

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

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Volume

81

Article Issue

4

Related Issue

18005

Issue Date

2020-10-01

Receive Date

2020-11-01

Publish Date

2020-10-01

Page Start

1,835

Page End

1,839

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 4_Pages 1835-1839.pdf

PDF . 956.6kB

Link

https://ejhm.journals.ekb.eg/article_121008.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=121008

Order

19

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Histological Structure of Pancreas in Chronic Pancreatitis and The Role of Pancreatic Stellate Cells

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Article

Created At

22 Jan 2023