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120459

Histological Structure of Dentate Gyrus in Global Cerebral Ischemia/Reperfusion Injury and Role of Nitraetes in Protection

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Last updated: 30 Jan 2023

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Abstract

Background: Ischemia-reperfusion injury is a hell mark of stroke that happens if blood supply is returned back after a period of ischemia. However, the benefit from restored blood supply by reperfusion can cause bad effect compared to permanent occlusion.
Objectives: This study aimed to analyze morphological alterations in dentate gyrus tissue during ischemia and its effects on histology of cells and to understand mechanisms of brain ischemia-reperfusion injury to develop effective therapy. Results: Many experiments proved that the mechanisms of ischemia-reperfusion injury include complement activation, leukocyte infiltration, oxidative stress, platelet adhesion and aggregation and mitochondrial-mediated mechanisms leading to blood-brain-barrier (BBB) disruption, which leads to brain edema.
Conclusion: In summary, over the past few years there have been significant advancement in our understanding of molecular and cellular mechanisms of ischemia-reperfusion injury in the brain. The major mechanisms of reperfusion injury are clear but are still far from being clinically successful. Thus, further investigations on brain reperfusion injury mechanisms are wanted. Also, role of nitrates in protection for ischemia-reperfusion brain injury.

DOI

10.21608/ejhm.2020.120459

Keywords

Blood-brain-barrier, complement, Dentate, gyrus, ischemia, reperfusion, mitochondria

Authors

First Name

Samah Sayed Hassan Elsayed

Last Name

Soliman

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Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

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First Name

Mostafa Mahmoud

Last Name

El-Habiby

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Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

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First Name

Neveen Mohamed

Last Name

El-Sherif

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Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

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Orcid

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First Name

Marwa Abdel-Samad

Last Name

Al-Gholam

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Affiliation

Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

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Volume

81

Article Issue

4

Related Issue

18005

Issue Date

2020-10-01

Receive Date

2020-10-26

Publish Date

2020-10-01

Page Start

1,828

Page End

1,834

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 4_Pages 1828-1834.pdf

PDF . 462.8kB

Link

https://ejhm.journals.ekb.eg/article_120459.html

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https://ejhm.journals.ekb.eg/service?article_code=120459

Order

18

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023