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Background: Neonatal jaundice is one of the most common neonatal problems especially in preterm ones. Preterm babies are treated with different types of phototherapy. Preterm neonates have a weak antioxidant defense mechanism. Both the hyperbilirubinemia and phototherapy have an impact on this antioxidant defense system.
Objective: In the current study we aimed to assess the effect of hyperbilirubinemia and phototherapy in the oxidant/antioxidant status of preterm newborns.
Subjects and Methods: Thirty late preterm (≥35 weeks) neonates with non-hemolytic neonatal jaundice in the 3-9 days of life were involved in the preset study, and received phototherapy. 15 healthy neonates of the same gestational and postnatal age without jaundice were included as a control. We assessed the total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI).
Results: TOS and OSI were significantly higher (P<0.01); TAC level was significantly lower (P<0. 01); in jaundiced preterm neonates than in control group. Following phototherapy there were significant increase in TOS and OSI (P<0. 01) and decrease in TAC (P<0.001).
Conclusions: Both hyperbilirubinemia and phototherapy induce oxidative stress in preterm neonates. Recommendations: preterm neonates with significant hyperbilirubinemia benefits of phototherapy overwhelm the risks.
DOI
10.21608/ejhm.2020.120450
Keywords
Preterms, Oxidants, antioxidants, Hyperbilirubinemia, Oxidative Stress
Authors
Affiliation
Department of Pediatric, Al-Azhar University, Assiut, Egypt
Email
khaledelenaizy@yahoo.com
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Department of Clinical Pathology, Al-Azhar University, Assiut, Egypt
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https://ejhm.journals.ekb.eg/article_120450.html
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https://ejhm.journals.ekb.eg/service?article_code=120450
Publication Title
The Egyptian Journal of Hospital Medicine
Publication Link
https://ejhm.journals.ekb.eg/
MainTitle
Impact of Phototherapy on Oxidative Stress Indices in Preterm Neonates with Unconjugated Hyperbilirubinemia