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120444

Dexamethazone Prophylaxis before Near Total Thyroidectomy to Reduce Vocal Dysfunction: A Randomized Clinical Trial

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Last updated: 30 Jan 2023

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Abstract

Background: Thyroidectomy operation is one of the most common operations around the world. There are different complications of thyroidectomy including vocal cords dysfunction, hypocalcaemia, pain, bleeding, hematoma, nausea and vomiting.
Objective: This study aimed to study the prophylactic effect of dexamethasone 8 mg/2ml amp, intravenous before near total thyroidectomy to reduce vocal dysfunction. Also, to study the effect in relation to pain, nausea, vomiting and hypocalcaemia.
Patients and Methods: This study was conducted in Mansoura University Hospitals, Endocrine Surgery Unit during the period between July 2018 and June 2019. All patients were admitted from the Outpatient Clinic. All patients were informed about the surgical procedure in the clinic and a written consent was taken from all patients participating in the study. Sample size was calculated using G- Power with effect size 0.8 and power of 0.8 where it was 100 patients (50 patients in each group).
Results: comparing the 2 groups postoperatively, the dexamethasone group had fewer complications as regards postoperative nausea, vomiting, pain, hypocalcaemia and vocal dysfunction.
Conclusion: From this study, it was shown that dexamethasone 8 mg/2ml IV before near total thyroidectomy has significant effect regarding reduction of postoperative nausea, pain, vomiting, hypocalcaemia and vocal cords mobility, which was less affected. In addition, there was no side effects of dexamethasone administration. Therefore, we advise to give dexamethasone to all patients before thyroid surgery.

DOI

10.21608/ejhm.2020.120444

Keywords

dexamethasone, near total thyroidectomy, vocal dysfunction

Authors

First Name

Atef Mohamed

Last Name

Abdel Latif

MiddleName

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Affiliation

Endocrine Surgery Unit, Faculty of Medicine, Mansoura University, Egypt

Email

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City

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Orcid

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First Name

Tamer Youssef

Last Name

Mohamed

MiddleName

-

Affiliation

Endocrine Surgery Unit, Faculty of Medicine, Mansoura University, Egypt

Email

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City

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Orcid

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First Name

Ahmed Elsayed

Last Name

Lotfy

MiddleName

-

Affiliation

Endocrine Surgery Unit, Faculty of Medicine, Mansoura University, Egypt

Email

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City

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Orcid

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First Name

Ahmed Helmy Mohamed

Last Name

Ahmed

MiddleName

-

Affiliation

Endocrine Surgery Unit, Faculty of Medicine, Mansoura University, Egypt

Email

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City

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Orcid

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Volume

81

Article Issue

4

Related Issue

18005

Issue Date

2020-10-01

Receive Date

2020-10-26

Publish Date

2020-10-01

Page Start

1,789

Page End

1,795

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 4_Pages 1789-1795.pdf

PDF . 540.3kB

Link

https://ejhm.journals.ekb.eg/article_120444.html

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https://ejhm.journals.ekb.eg/service?article_code=120444

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12

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

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Article

Created At

22 Jan 2023