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116791

Evaluation of Serum RANTES as a Biomarker in the Diagnosis of Early-Onset Neonatal Infections

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Last updated: 03 Jan 2025

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Abstract

Background: Globally, sepsis is still one of the major causes of morbidity and mortality in neonates, despite recent advances in health care units.
Objective: To assess the accuracy of serum chemokine RANTES as a biomarker for early-onset neonatal infection as early diagnosis and to assess its relationship with gestational age, birth weight, sex, mode of delivery, and value of some hematological and biochemical parameters facilitating early good treatment.
Patients and Methods: This case-control study was carried out on neonates with early-onset neonatal infections that were admitted to the Neonatal Intensive Care Unit of Zagazig General Hospital. This study included 45 matched age and sex neonates divided into three groups.
Results: Significantly higher levels of RANTES were found in neonates with EONS compared with non-infected cases. RANTES levels were significantly higher in infected term &preterm neonates compared to healthy controls. Infected full-term neonates had higher RANTES levels than in infected preterm neonates without a statistically significant difference. A positive correlation between serum RANTES concentration and CRP value was found in both infected neonates groups. On the other hand, no correlation between RANTES and the number of white blood cells, platelets, or hemoglobin was noted.
Conclusion: The significant increase of serum RANTES concentration in early-onset infections in neonates, regardless of their gestational age, birth weight, and Apgar score, not only proves the presence of an active immunological process but also may be a useful biomarker for diagnosis of early-onset severe neonatal infections.

DOI

10.21608/ejhm.2020.116791

Keywords

RANTES, biomarker, early, Onset Neonatal Infections

Authors

First Name

Mahmoud Mohammed

Last Name

Abd-Elsamea

MiddleName

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Affiliation

Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Email

mahmod.mohmed222@gmail.com

City

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Orcid

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First Name

Azza I.

Last Name

El-dousoky

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Email

-

City

-

Orcid

-

First Name

Hadeel M.

Last Name

Abd El-Rahman

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Email

-

City

-

Orcid

-

First Name

Randa Hussiny

Last Name

Mohammad

MiddleName

-

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Sharkia, Egypt

Email

-

City

-

Orcid

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Volume

81

Article Issue

3

Related Issue

17515

Issue Date

2020-10-01

Receive Date

2020-10-03

Publish Date

2020-10-01

Page Start

1,609

Page End

1,613

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 3_Pages 1609-1613.pdf

PDF . 568.5kB

Link

https://ejhm.journals.ekb.eg/article_116791.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=116791

Order

12

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Evaluation of Serum RANTES as a Biomarker in the Diagnosis of Early-Onset Neonatal Infections

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Article

Created At

22 Jan 2023