Background: There are many risk factors for Preterm Premature Rupture of Membranes (PPROM). Infection is the main one (15-25%), especially at earlier gestational ages. Neonatal respiratory distress syndrome of the neonate is an important obstacle in cure of preterm infants. Objective: To assess the efficacy of the amniotic fluid lamellar body counting (LBC) from vaginal pool in predicting fetal lung maturity in women with preterm premature rupture of membranes. Patients and Methods: This study was conducted on 92 cases. Prediction of fetal lung maturity and the presence of respiratory distress syndrome (RDS) were estimated. LBC was measured for all cases. Results: There were a significant negative correlation between respiratory distress syndrome and gestational age. Also a significant correlation between level of LBC and fetal lung maturity using 38.0 (x103 /μL) as a cutoff point for LBC; as it is can be considered a good predictor for fetal lung maturity with sensitivity 92.9% and specificity 90.6%, positive predictive value of 81.3% and negative predictive value of 96.7%. Conclusion: There is a significant correlation between level of LBC and fetal lung maturity. LBC could be considered a good predictor for fetal lung maturity.