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115632

Association between Glycemic Control and Birth Weight with Glycated Albumin in Women with Gestational Diabetes Mellitus

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Last updated: 03 Jan 2025

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Abstract

Background: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is primarily detected during pregnancy.
Objective: To determine the relationship between glycemic control and glycated albumin in women with GDM. Patients and Methods: This prospective study was carried out in the Department of Obstetrics and Gynecology, Zagazig University Hospitals, Zagazig, Sharkia, Egypt from December 2018 to October 2019. The study included 30 patients suffering from GDM (study group) as well as another matching 30 women (control group). Maternal screening for all cases at 24-28 wks using a 75-gm oral glucose tolerance test (OGTT) which is a fasting blood glucose sample was done.
Results: GA levels were significantly higher after 24 weeks of gestation in the GDM group compared with controls. Elevated GA levels had a positive correlation with birth weight. In the present study, fetal weight was significantly higher among the study group (3850.0±513.7) than controls (3396.6±334) (p < 0.001). Glycated albumin, HbA1c only showed association with large‐ for‐ date status. Also, GA24_28, more than 13.4 had a sensitivity of 82% and specificity of 72% for GDM. ROC curve, as the cut‐ off point for identifying poor glycemic control in GDM women, and provided the optimal sensitivity (75.93%) and specificity (86.36%).
Conclusion: GDM women, the risk of macrosomia significantly increases when the GA levels are ≥14.45% in the third trimester. The results provide strong support for the use of GA measurements, as a complement to finger stick glucose, for assessing short‐ term glycemic control and predicting large birth weight in the GDM women.

DOI

10.21608/ejhm.2020.115632

Keywords

Glycemic control, birth weight, Glycated albumin, Gestational diabetes mellitus

Authors

First Name

Mohammed Najib

Last Name

Azzam

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

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City

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Orcid

-

First Name

Mohammed Sabry

Last Name

Mahdy

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

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City

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Orcid

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First Name

Mustafa Taha

Last Name

Abdelfattah

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

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City

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Orcid

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First Name

Sarah Elsayyed Ibrahim

Last Name

Abdalrahman

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt

Email

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City

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Orcid

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Volume

81

Article Issue

3

Related Issue

17515

Issue Date

2020-10-01

Receive Date

2020-09-27

Publish Date

2020-10-01

Page Start

1,552

Page End

1,557

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 3_Pages 1552-1557.pdf

PDF . 730.1kB

Link

https://ejhm.journals.ekb.eg/article_115632.html

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https://ejhm.journals.ekb.eg/service?article_code=115632

Order

3

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Association between Glycemic Control and Birth Weight with Glycated Albumin in Women with Gestational Diabetes Mellitus

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Type

Article

Created At

22 Jan 2023