Background: Hepatitis C virus (HCV), hepatitis B virus (HBV) and human immunodeficiency virus (HIV) are the commonest chronic viral infections worldwide, they share most common routes of infections, they are hepatotropic viruses and their combined infections had bad outcome on the liver. Objective: To evaluate the risk of coinfection of the liver by both HCV, HBV and HIV on the liver outcome. Patients and Methods: This is a retrospective study of 241 patients attending different fever hospitals coinfected by HCV and or HBV with HIV but not HCV or HBV without HIV infections. Result: There was significant difference between male 59.8% and female 40.2%, age of patients, also there was significant difference as regard liver enzymes, cirrhosis, splenomegaly, international normalization ratio in triplet coinfections. Conclusion: There is high risk on liver outcome in the presence of coinfection between HCV or HBV and HIV.