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113393

Oral Gabapentin versus Pregabalin for Postoperative Pain Relief in Elective Cesarean Section Patients under Spinal Anesthesia

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Last updated: 03 Jan 2025

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Abstract

Background: Pain after Cesarean delivery is the main postoperative complain in parturients, pregabalin and gabapentin have been shown to decrease acute postoperative pain in parturient. Objective: The aim of the study was to compare gabapentin and pregabalin as oral premedication in patients for elective cesarean section under spinal anesthesia for postoperative pain relief and the need to rescue analgesia.
Methods: This study was carried out at Obstetric Operating Rooms, Zagazig University Surgical Hospitals. The study included 54 consenting women aging 20ā€“40 yrs old with uncomplicated pregnancies that were scheduled to undergo elective Cesarean section delivery under spinal anesthesia. They were randomly allocated into three equal groups. Group (P) received 300 mg pregabalin, group (G) received 900 mg gabapentin, and control group (C). The study medication given orally one hour before the anticipated time of the surgical incision, and data measured included visual analogue scale (VAS), the total doses of analgesia, the incidence of post-operative nausea and vomiting (PONV) and the level of sedation. Results: The VAS was comparatively low in patients of group P as compared to G and C groups (P value < 0.05). Total analgesic requirement of pethidine in first 24 h was significantly lower in groups P as compared to groups G & C (P value < 0.001). We found that there was statistically significant increase in the sedation scores of the patients in P group as compared to G & C groups.
Conclusion: Pregabalin 300 mg was more effective than gabapentin300 mg in reducing post Cesarean section pain, opioid consumption, nausea, and vomiting.

DOI

10.21608/ejhm.2020.113393

Keywords

cesarean section, Postoperative Pain, Pregabalin, Gabapentin

Authors

First Name

Neveen Mahmoud

Last Name

Alaasar

MiddleName

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Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University

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Orcid

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First Name

Dalal El-sayed Mohammed

Last Name

soud

MiddleName

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Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University

Email

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City

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Orcid

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First Name

Asmaa Mohammed

Last Name

Galal El-Deen

MiddleName

-

Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University

Email

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City

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Orcid

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First Name

Ahmad Ibraheem Ahmad

Last Name

Abd Elfattah

MiddleName

-

Affiliation

Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Zagazig University

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-

City

-

Orcid

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Volume

81

Article Issue

1

Related Issue

16813

Issue Date

2020-10-01

Receive Date

2020-09-18

Publish Date

2020-10-01

Page Start

1,330

Page End

1,337

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 1_Pages 1330-1337.pdf

PDF . 585.0kB

Link

https://ejhm.journals.ekb.eg/article_113393.html

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https://ejhm.journals.ekb.eg/service?article_code=113393

Order

29

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Oral Gabapentin versus Pregabalin for Postoperative Pain Relief in Elective Cesarean Section Patients under Spinal Anesthesia

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Article

Created At

22 Jan 2023