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The Possible Protective Effect of Platelet Rich Plasma on Aspirin Induced Gastric Ulcer in Adult Male Albino Rat

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Last updated: 24 Dec 2024

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Abstract

Background: High morbidity and mortality due to gastric ulcer made its management is a medical challenge. Platelet rich plasma (PRP) had been used for treatment of skin ulcers, some hair and bone problems as PRP contains many growth factors which make it suitable for management of gastric ulcer.Objectives: The current work was aimed to study the protective role of PRP on gastric ulcer induced by aspirin. Materials and Methods: Forty adult male albino rats were divided into four groups. Group I; sham control, group II received PRP, group III received aspirin for induction of gastric ulcer and group IV was provided with PRP then received aspirin. All rats were sacrificed then the fundic mucosa was processed for light and scanning electron microscopic study. Paraffin sections were stained by hematoxylin and eosin, mallory trichrome and combined periodic acid Schiff (PAS) and alcian blue (AB) stains. Immunohistochemical staining for iNOS and EGFR were also performed. Results: Aspirin had induced mucosal destruction in the form of ulceration, epithelial surface desquamation, hemorrhage, vacuolation and inflammatory cellular infiltration. Scanning electron microscopic examination of aspirin group showed decreased mucus, widening of gastric pits and cavitation of mucosal folds. PRP produced a great preservation of gastric structure in protected group (IV). Conclusion: It could be concluded that aspirin caused ulcerating changes in gastric mucosa and PRP had ameliorating effects on these changes.

DOI

10.21608/ejhm.2020.112312

Keywords

aspirin, Gastric ulcer, PRP, Scanning Electron Microscopy

Authors

First Name

Fatma Fawzy

Last Name

Nada

MiddleName

-

Affiliation

Department of Anatomy, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

dr_fatmanada@yahoo.com

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Orcid

-

First Name

Fatma El-Nabawia A.

Last Name

El-Safty

MiddleName

-

Affiliation

Department of Anatomy, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Abeer E.

Last Name

El –mehi

MiddleName

-

Affiliation

Department of Anatomy, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

First Name

Noha M.

Last Name

Issa

MiddleName

-

Affiliation

Department of Anatomy, Faculty of Medicine, Menoufia University, Menoufia, Egypt

Email

-

City

-

Orcid

-

Volume

81

Article Issue

1

Related Issue

16813

Issue Date

2020-10-01

Receive Date

2020-09-13

Publish Date

2020-10-01

Page Start

1,240

Page End

1,250

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 81_Issue 1_Pages 1240-1250.pdf

PDF . 1.6MB

Link

https://ejhm.journals.ekb.eg/article_112312.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=112312

Order

14

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

The Possible Protective Effect of Platelet Rich Plasma on Aspirin Induced Gastric Ulcer in Adult Male Albino Rat

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Article

Created At

22 Jan 2023