Background: Jaundice is the most common condition that requires medical attention in newborns. The yellow coloration of the skin and sclera in newborns with jaundice is the result of accumulation of unconjugated bilirubin. Objectives: To assess the efficacy of intensive phototherapy as a treatment modality for neonatal hyperbilirubinemia. Subjects and methods: This was A prospective, cohort, controlled study that was conducted on 100 babies with neonatal jaundice. They were admitted to Luxor General Hospital NICU at the beginning of November 2018 to the end of October 2019. Those 100 cases had been divided into 2 groups: the first group received intensive phototherapy sessions as a treatment modality for neonatal jaundice and the second group received conventional phototherapy. Results: The results of the study revealed that intensive phototherapy had succeeded in decreasing the need for exchange transfusion in 39 cases (78 %), whereas 11 cases (22%) remained for exchange transfusion (p value (0.001) was highly significant). Conclusion: The use of intensive phototherapy in the treatment of indirect pathological hyperbilirubinaemia is as effective as exchange transfusion in lowering total serum bilirubin when its level is within 2-3 mg/dl (34-51 µmol/l) of the exchange level and it is effective in reducing needs for exchange transfusion and duration of phototherapy.