Background: Hepatocellular carcinoma (HCC) is the most typical primary viscus malignancy and also the second leading reason behind cancer-related death worldwide. Objectives: To study the association between the tomography and pathological options of HCC for getting an honest designation on the lesions of HCC for getting the best treatment and prognosis of these lesions. Patients and Methods: Study of the imaging criteria of HCC which includes the arterial enhancement and venous washout in both CT and MRI within a background of cirrhosis, and it's a possible association with the vascular density and microvascular invasion seen in the biopsy. We enrolled consecutive cirrhotic patients with HCC liver resection in 2 years (from January 2018 till December 2019). Results: Our results on the number of lesions cleared that, the number of lesions ranged from 1 in number that observed in 68 (66.02 %) and 2 that observed in 11 (10.68 %), followed by 3, 4, and 5 lesions that observed in 1 (0.97 %) of the examined patients. The higher incidences of the lesions observed in middle hepatic vein 55 (53.40 %) right lobe of the liver 16 (15.54 %) , seg 2/3 10 (9.71 %), right liver 5 (4.86 %), left liver 5 (4.86 %) and in left lateral liver 4 (3.88 %). Conclusion: The association between the Imaging and pathological features of HCC including microvascular invasion and density which is very important for getting an honest designation on the lesions of HCC and for getting the best treatment and prognosis of these lesions.