Background: Acute lymphoblastic leukemia (ALL) survivors received blood transfusions for multiple times during treatment are at great risk for HCV infection. Rapid progression to cirrhosis in those patients is a concern for cancer survivors because of the immunosuppression from cancer-related treatment. Objective: Our study aimed to screen for (HCV) infection in acute lymphoblastic leukemia (ALL) survivors. Patients and methods: This cross-sectional study was conducted in the Hematology and Oncology Department of Children Hospital-Zagazig University on 80 cancer survivors collected over a period of 6 months from September 2018 to February 2019. Results: 70% of ALL survivors were HCV positive. Conclusion: ALL survivors are at great risk for acquiring HCV infection from the repeated blood and blood products transfusions with supsequent development of liver comorbitidites later on.