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90163

Prevalence of Thyroid Function Abnormalities in Patients with Chronic Renal Failure under Regular Hemodialysis

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Last updated: 03 Jan 2025

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Abstract

Background: There are various changes in the thyroid gland and its function in end stage renal disease (ESRD). It is not surprising that impairment of kidney function leads to disturbed thyroid physiology. Objective: Is to detect thyroid function abnormalities in hemodialysis patients. Patients and Methods: 100 patients on maintenance hemodialysis (HD) were enrolled, they were excluded if they had the following criteria: history of thyroid disease, thyroid and parathyroid surgery, under interferon therapy, exposed to radiation, antithyroid drugs or thyroid replacement therapy, and those under 30 years. They were subjected to history taking, clinical examination and laboratory investigations including hepatitis C virological state, renal functions and thyroid functions. Results: 92% of patients had normal thyroid-stimulating hormone (TSH) levels, 8% had abnormal TSH levels. Regarding fT3 levels, 67 % had normal fT3 while 33 % had abnormal fT3, and only 11 patients had abnormal fT4. In respect to the thyroid hormone status, only one was hyperthyroid, 92% were in euthyroid status, 2% were clinically hypothyroid, 5% were subclinically hypothyroid, and 1% was hyperthyroid. There was significant negative correlation between TSH levels and dialysis duration, 8 patients having abnormal thyroid functions ere females, and 60% had HCV positive status. No significant associations were found between HCV infection and the thyroid hormones levels. However, HCV positive patients experienced lower levels of T4 and TSH. Conclusion: The average percentage of patients under regular hemodialysis with abnormal thyroid state is 8% with females having abnormal fT4 and TSH levels compared to males. TSH levels were inversely correlated with dialysis duration.

DOI

10.21608/ejhm.2020.90163

Keywords

Hepatitis C virus, Free T3, Free T4, TSH, HD

Authors

First Name

Walid

Last Name

Bichari

MiddleName

-

Affiliation

Nephrology Department, Faculty of Medicine - Ain Shams University, Cairo, Egypt

Email

bichari2005@yahoo.com

City

-

Orcid

-

First Name

Essam

Last Name

Khedr

MiddleName

-

Affiliation

Nephrology Department, Faculty of Medicine - Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Husein

Last Name

Sayed

MiddleName

-

Affiliation

Nephrology Department, Faculty of Medicine - Ain Shams University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

Elwasly

MiddleName

-

Affiliation

Nephrology Department, Faculty of Medicine - Ain Shams University, Cairo, Egypt

Email

dr.dodoelwasly@hotmail.com

City

-

Orcid

-

First Name

Haitham

Last Name

Ezzat

MiddleName

-

Affiliation

Nephrology Department, Faculty of Medicine - Ain Shams University, Cairo, Egypt

Email

haitham_ezzat@hotmail.com

City

-

Orcid

-

Volume

80

Article Issue

1

Related Issue

13031

Issue Date

2020-07-01

Receive Date

2020-05-17

Publish Date

2020-07-01

Page Start

594

Page End

598

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 80_Issue 1_Pages 594-598.pdf

PDF . 470.8kB

Link

https://ejhm.journals.ekb.eg/article_90163.html

Detail API

https://ejhm.journals.ekb.eg/service?article_code=90163

Order

7

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Prevalence of Thyroid Function Abnormalities in Patients with Chronic Renal Failure under Regular Hemodialysis

Details

Type

Article

Created At

22 Jan 2023