Background: Fetuin-A is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Objective: To investigate the relationship of fetuin-A with and insulin resistance in type- II diabetics either obese or non-obese of Zagazig University, Shatkia Governorate, Egypt. Patients and Methods: This is a case-control study that was conducted at the Internal Medicine Department of Zagazig University. Seventy-five participants were divided into three groups. Group-A (n =25) normal healthy individual, Group-B (n =25) non-obese type 2 diabetic patients and Group C (n=25) obese type 2 diabetic patients. Type 2 diabetic patients with no morbidities. Serum fetuin-A and insulin levels were performed by ELISA kits while fasting blood glucose (FBG), 2HPP and HA1C were determined by the enzymatic kit method. A comparison of groups was done and correlation was achieved by using Spearman correlation. Results: The results demonstrated a significant difference in mean values of fetuin-A, BMI, WHR, fasting blood glucose (FBG), 2HPP, HA1C, insulin level and Homoeostasis Model Assessment of Insulin resistance (HOMAIR) in type-II diabetics when compared to normal healthy individuals and obese type-II diabetics (p<0.01). The fetuin-A level was higher in obese more than non-obese type II diabetics. Conclusion: The study concluded that fetuin-A might be accountable for insulin resistance in type-II diabetes mellitus either obese or non-obese. So the high levels of Fetuin-A responsible for insulin resistance.