Background: Type 2 diabetes mellitus ((T2DM) is one of the most challenging health problems of the twenty-first century. A further 318 million adults are estimated to have impaired glucose tolerance, which puts them at high risk of developing the disease. (T2DM remission has been reported to varying degrees after all current bariatric operations. Objective: The aim of this study was to evaluate if laparoscopic mini gastric bypass (MGB) operation is effective for treatment of (T2DM associated with morbid obesity. Material and methods: This prospective study included a total of 100 patients with morbid obesity submitted to Laparoscopic MGB from March 2018 to January 2019. This comprises the initial part of our series, and data was analyzed after all patients completed a follow up of 1 year. This study was conducted in the Bariatric Surgery Unit, at Assuit university hospital and Osama Taha group clinic. Demographic and clinical data were prospectively collected from the preoperative evaluations. Results: Diabetic patients showed significant decrease in random blood sugar (RBS) and HA1c in 1 year follow up after surgery. The mean RBS preoperative was 294.40±57.13 while after 1 year follow up was 182.38±4.71 and significant decrease in HA1C from mean 8.24±1.91 to 5.61±1.20 1 year after surgery. Remission was achieved in 92% with (86.0%) of patients have complete remission, and (6.0%) of patients have partial remission. In this study The DM complete remission rates for those with disease duration < 2years, 2-5 years and > 5 years were 93.02%, 66.67% and 25% respectively. Conclusion: It could be concluded that one-Anastomosis Gastric Bypass (OAGB) can be an excellent alternative to Roux-en-Y Gastric Bypass (RYGB) for the treatment of diabetes and obesity. Pre-operative medications and duration of disease may be used to predict postoperative diabetes remission.