Background: In recent years, a surgical technique known as single-anastomosis gastric bypass (SAGB) or minigastric bypass (MGB) has been developed. Its frequency of performance has increased considerably in the current decade. This procedure proposes a simplification of Roux-en-Y bypass by performing a single anastomosis, with a significant reduction of technical complexity, shorter operative time and a potential reduction in morbidity and mortality. Objective: This study aimed to evaluate if laparoscopic mini gastric bypass operation is safe and effective for treatment of different cases with morbid obesity and its associated comorbidities Material and methods: This was a prospective study of 100 patients with morbid obesity submitted to laparoscopic MGB from March 2018 to January 2019. This study was conducted in the Bariatric Surgery Unit, at Assuit university hospital and Osama Taha group clinic. Demographic and clinical data were prospectively collected from the preoperative evaluations. Results: The most important findings of this study were the safety and the high efficacy, which were translated into no mortality, very acceptable complications (early complication rate 4% and late complication rate 6 %). High excess weight loss (EWL) 72.26 ± 5.18 % and remission rate 92% of patients who had diabetes, as 100.0% of patients who had fatty liver, 96.0% of patients who had hyperlipidemia, 95.0% of patients who had sleep apnea and 94.0% of patients who had hypertension. Conclusion: MGB/ one-anastomosis gastric bypass (OAGB) is a simple, safe, effective, easy to learn and easy to reverse procedure. It has acceptable complications and mortality rates.