Background: Acute kidney injury (AKI) is a frequent complication in patients admitted to the intensive care unit (ICU) and is associated with adverse outcomes including increased length of ICU and hospital stay, development of chronic kidney disease (CKD) and increased short- and long-term mortality risk. Objective: To screen critically ill patient admitted to ICU in Aswan University Hospital for acute kidney injury from September 2017 up to September 2018. Patients and methods: In this study 538 patients were admitted to the ICU in Aswan University Hospital in Egypt, from August 1st, 2017 to August 1st 2018. This study was a prospective, randomized; hospital based clinical study on critically ill patients in Intensive Care Unit. With inclusion criteria patients who were 18 years or older and admitted to the Intensive Care Unit (ICU). Results: Out of 583 patients admitted to ICU, there were 97 patients had AKI, 64.9% of them already had AKI on the admission while the rest of them (35.1%) developed AKI after admission. There is more than one third of mortality among ICU patients related to AKI (35.1%), while (64.9%) were related to other causes. Conclusion: AKI is associated with high mortality in our ICU setting. Further studies are needed to estimate the burden of AKI among patients before ICU admission