Background: Cardiovascular changes are associated with Liver cirrhosis so, it is important to assess its function in cirrhotic patients. Child-Pugh scoring system is the simplest clinical method used for classifying liver cirrhosis. 3D echo and 2D speckle tracking echocardiography (2D-STE) are the most recent imaging modalities able to evaluate LV systolic function accurately. Aim: To assess LV systolic function in patients with chronic liver cirrhosis caused by HCV by different echocardiographic modalities including 3D and STE and correlation of the results with the severity of cirrhosis based on Child-Pugh score. Material and methods: A prospective study was done in Cardiology Department, AlZahraa University Hospital including a total of 75 subjects; 45 cirrhotic patients and 30 subjects as a control. 2D, 3D LV volumes and EF and 2D-STE of the LV were measured. Then, the patients' group was divided into 3 subgroups according to Child Pugh score then LV systolic function were assessed with different echo modalities (2D, 3D and MM, TDI (Sm) and, 2D STE). Results: The LVEF increased significantly in patient group by M-mode and 2D but decreased by TDI, 3D echo and STE. Increased systolic velocity (Sa) by TDI in group III of cirrhosis but lowered systolic function by using STE. Also, there was a significant correlation between severity of liver cirrhosis and LVEF by 2D STE, 3D and 2D. Conclusions: The recent noninvasive 3D echo and 2-D STE techniques are a promising methods for early detection of LV systolic dysfunction in asymptomatic patients with viral liver cirrhosis. Also, the LV systolic dysfunction is related to the extent of severity of liver cirrhosis.