Background: Hyponatremia is a frequent complication of advanced chronic liver diseases related to an impairment in the renal capacity to eliminate solute-free water that causes a retention of water that is disproportionate to the retention of sodium, thus causing a reduction in serum sodium concentration and hypoosmolality. Objective: The aim of this study is to evaluate the role of hyponatremia on morbidity and mortality in chronic liver diseased patient in ICU unit at Aswan University Hospital. Matients and methods: This study included 90 patients who were suffering of hyponatremia with chronic liver disease and selected from patients in Aswan University Hospital. The patients were 61 males (67.78%) and 29 females (32.22%). Results: About (40%) of patients were discharged and (60%) of patients died. First group: patients with mild hyponatremia about (67.71%) were discharged and about (35.29%) died. Second group: patients with moderate hyponatremia about (65.7%) were discharged and about (34.21%) died. Third group: all patients with severe hyponatremia (100 %) died. Conclusion: hyponatremia play important role in mortality rate of patients with chronic liver disease.