Background: Radical cystectomy remains the gold standard in treatment of muscle invasive bladder cancer. Objective: To evaluate the quality of life (QOL) for patients underwent ileal conduit (IC) versus orthotopic ileal neobladder (INB) urinary diversions (UD) after one year post radical cystectomy (RC). Patients and methods: Our study was a retrospective study that included patients with MIBC who underwent RC and UD from January 2014 to Julie 2018 that passed one-year post RC. There were two groups of patients as follows: IC and INB groups. QOL was evaluated by the Functional Assessment of Cancer Therapy– Bladder Cancer (FACT-BL). The erectile function (EF) was assessed by the International Index of Erectile Function-5 (IIEF-5) questionnaire. Results: Overall, 125 patients underwent RC with UD were screened for eligibility. Twenty patients (16%) died, 11 patients (8.8%) failed to reach to them, 6 patients (4.8%) underwent other UD and 2 patients (1.6%) refused participation in this study thus 86 patients (68.8%) were eligible for the study and were analyzed. The mean patient's age was 61.6 ± 6.3 in both groups (p value 0.199). There were significant differences between both groups in physical, social, emotional, functional, additional concerns, urinary and GIT symptoms that were significantly better in INB group (p value < 0.001). There was no significant difference between both groups regarding the EF. Conclusions: the INB is better than the IC UD in most of QOL domains, which include physical, social, emotional, functional, additional concerns, urinary and GIT symptoms. But sexual function remains equal bad in both groups.