Background: Weaning has been one of the most wrongly practiced processes in the developmental stages of the children. Objective: The aim of the work was improving knowledge and practice of mothers regarding weaning diet. Subjects and methods: Across sectional study was performed on 323 mothers attended maternal and childcare center in Tour Sinai City. Structured questionnaire was used included sociodemographic data, knowledge and practice regarding infant weaning. Results: revealed that the mothers belonging to the age group 20-35 (84.8%), secondary education (39.6%), with current occupation (60.1%), and with enough income (79.9%) were classified as medium social class. Level of mothers' knowledge and practice was moderate (50-70%) and there was highly statistical significance association (P<0.001**) between social class and level of mothers' knowledge and practice. Social class was the only significant factor affecting knowledge and practice where moderate knowledge was noticed in medium social class, moderate practice was associated with high social class. There was statistically significant positive correlation between total score of knowledge and total score of practice. Conclusion: Knowledge and practice among the participants were of moderate level and social class was the only factor affecting it.