Background: Central giant cell granuloma (CGCG) is a benign aggressive destructive osteolytic lesion of osteoclastic origin. The central giant cell granuloma is often found in the mandible, anterior to the first molars. It most commonly occurs in patients under the age of 30, with a clear female prevalence. Objectives: The aim of this report was to present a case of CGCG of the mandible and to describe the effect of platelet rich fibrin along with the surgical treatment on such aggressive lesions. Patients and methods: A 29 years old man referred from Hafer Albaten General Hospital to our Department of Oral and Maxillofacial Surgery with a chief complaint of painless swelling on the left lower back jaw region for 6 months. An unusual treatment modality had been carried out in Department of Oral and Maxillofacial Surgery at Alrass General Hospital. Aggressive curettage along with peripheral osteotomy has been done followed by reconstruction with Platelet rich fibrin (PRF) as an autologous grafting material. Results: A Three months, six months, One year and Two years follow up revealed a good healing of the osseous lesion with no signs of recurrence. Conclusion: Curettage of the tumor mass, followed by the removal of the peripheral bony margins results in a low recurrence rate and good prognosis.