Aim of the work: aluminum chloride (AlCl3) toxicity to animals and human increased in the last decade. Thereby, this study evaluated the potential ameliorative role of curcumin phytosome (CP) on AlCl3-induced nephrotoxicity. Material and methods: rats were allocated into four groups (n=6), Control group; CP group: rats orally administered with CP (200 mg/kg b.wt.) for 21 days; AlCl3 group, intraperitoneally injected with three doses of AlCl3 (30 mg/kg/b.wt.) every five days; group AlCl3 and CP, rats received CP for 7 days prior to AlCl3 and then received CP concurrently with AlCl3 for another 14 days. Results: AlCl3 acquaintance significantly increased levels of creatinine, urea, uric acid, LPO and NO as well as reduced renal GSH, SOD and GPx activity in comparison with the control group. These biochemical variations linked with histological renal atrophy and morphological lesions in the glomeruli and the different renal tubules. All these biomarkers in addition to the histopathological changes of injured kidneys were distinctly reversed after treatment with CP. CP is effective in mitigating the nephrotoxicity evoked by AlCl3 through restoring the oxidant/antioxidant equilibrium. The pathway of renal ameliorative effect of curcumin phytosome may be related to its ability to decrease MDA and other ROS and increase of antioxidants activity.