Background: Chronic renal failure is a universal community health problem. It is important to the patient to be on a specific healthy diet program. Objective: The present study was conducted to evaluate the effect of a specified nutritional program on the health status of renal patients on hemodialysis. Patients and methods: This was an interventional study that was conducted in the renal dialysis unit in El-keman village, Luxor Governorate. It included 60 patients with chronic renal failure on hemodialysis. An educational nutritional program was designed for the studied group. The patients were assessed pre- and post-intervention. The collected data were analyzed by using SPSS program version 19 with considering statistical significance when P value < 0.05. Results: The mean age of the studied participants was 46 years with age ranging from 20-60 years old. Nearly 56.7% of the patients were males and 51.7% of them were of low social class. Regarding the Mini Nutritional Assessment (MNA), there was highly statistically significant difference in MNA score before and after intervention (25.07 versus 22.45 respectively) and there was marked significant reduction in malnutrition percentage after the intervention. Creatinine, urea, AST, ALT and cholesterol significantly decreased after intervention compared to the levels before it. There was highly statistically significant improvement in hemoglobin level after intervention. Conclusion: It can be concluded that proper nutrition is important for patients on hemodialysis as good nutritional status of the patients affects greatly their quality of life and health status.