Background: Patients with vitroreinal diseases require surgical intervention frequently have coexisting lens opacification. Cataracts increase in prevalence with age, as do vitreoretinal pathologies such as macular holes, epiretinal membranes, and retinal detachments. Diabetes is another contributing factor that results in the development of both retinal disease and cataracts. In addition, vitrectomy itself causes cataracts to progress. Objective: The aim of the work to review the results and complications of combined phacoemulsification and vitrectomy in presbyopic patients with clear crystalline lens and compare it with the results and complications of separate surgeries. Patients and methods: This study carried on 40 presbyopic patients with clear lens having complex vitreoretinal disease in which vitrectomy is essentially required such as primary rhegmatogenous retinal detachement, recurrent rhegmatogenous retinal detachement, full thickness macular hole Stages 3,4,5, idiopathic epiretinal membrane, proliferative diabetic retinopathy and vitreous hemorrhage. Result: There is no difference between the groups regarding sex, diagnosis, used material, VA, and IOP. VA showed improvement in both groups at the same degree post operatively. But there is no change in the IOP postoperatively compared to the preoperative measurement in both groups. The only complication that showed significant difference between the two groups is the visually significant PCO which occurred in 2 cases (9.5%) in the Combined Phaco Vitrectomy compared to 10 cases of PSC in the PPV alone group (43.5%). Conclusion: Our study provides evidence that combing phaco and vitrectomy has more efficacy vitrectomy alone then phaco regarding visual acuity improvement with lower incidence of complications.