Background: hemostasis, throughout and after endonasal surgery, still raise loads of debates as regarding the foremost optimal technique as regard the efficacy, patient comfort, risks and costs. Objective: assessment of the worth of applying the intranasal surgicel® sheet after partial inferior turbinectomy (PIT) surgery Patients and Methods: a prospective, randomized comparative study was conducted from July 2015 to July 2018 at Al-Azhar University hospitals. A total of hundred and twenty patients underwent bilateral PIT. They were randomly divided into a pair of groups; group A enclosed sixty patients had PIT with intranasal surgicel® sheet application and group B enclosed sixty patients had PIT without surgicel® sheet. A comparison was made between the two groups at three time points; forty eight hours, one week, and four weeks postoperatively. Results: at forty eight hours after surgery, number of patients reported milder pain before and after pack removal in group A were significantly higher than patients within the group B. Patients in Group A bled less with shorter hemostasis time than those in group B. At one week postoperatively; visual analogue score (VAS) for pain was significantly less in group A with a better healing. At four weeks postoperatively; healing was significantly better in group A. Conclusion: the utilization of intranasal surgicel® sheet after PIT can decrease pain and bleeding and lessen hemostasis duration during pack removal and decreased postoperative pain with decreasing rates of intranasal adhesions.