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46750

Assessment of Left Ventricular Function and Contractile Reserve in Patients with Hypertension

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Last updated: 03 Jan 2025

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Abstract

Background: Hypertension is a prevalent and well-recognized cardiovascular risk factor, which may lead to left ventricular (LV) systolic impairment through chronic pressure overload. Aim of the work: An impaired contractile reserve (CR) may be an early manifestation of left ventricular (LV) systolic dysfunction in hypertensive patients. Using normotensive patients as controls, we examined LV CR and its correlates in hypertensive patients. Material and methods: The study was conducted prospectively on fifty cases. 30 cases (24 males and 6 females aged 55.57 ± 10.07) had hypertension. All patients were subjected to complete history taking including comorbidities, risk factors and full clinical examination. Patients with significant coronary or valvular disease, previous myocardial infarction or revascularization and diabetes were excluded. LV ejection fraction (LVEF) & global longitudinal strain (GLS) were measured at rest and at low-dose dobutamine. Results: Hypertensive patients, compared to control had significantly impaired GLS at rest (-19.00 ± 2.34% vs. -20.50 ± 1.52%, P <0.015) and at low dobutamine dose (-19.90 ± 2.33% vs. -22.60 ± 1.88 %, P <0.001). Absolute and relative GLS CR were significantly lower in hypertensive patients (-0.88 ± 0.45% vs.-2.12 ± 0.77% and 4.70 ± 2.76% vs. 10.33 ± 3.78 %, respectively, both P < 0.001). Absolute and relative LVEF CR were significantly lower in hypertensive patients (3.31 ± 0.97 % vs. 7.09 ± 1.67% and 5.37 ± 1.64% vs. 11.61 ± 3.19%, respectively, both P < 0.001). Conclusion: Compared to control, hypertensive patients with no other co-morbidities had impaired LV GLS at rest and impaired CR despite normal LVEF.

DOI

10.21608/ejhm.2019.46750

Keywords

Hypertension, Ventricular function, contractile reserve, Echocardiography, Speckle tracking strain

Authors

First Name

Kamal Ahmed

Last Name

Marghany

MiddleName

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Affiliation

Department of Cardiology - Faculty of Medicine, Al-Azhar University

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City

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Orcid

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First Name

Abd-Elhamid Ismail

Last Name

Abu Rahhal

MiddleName

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Affiliation

Department of Cardiology - Faculty of Medicine, Al-Azhar University

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Orcid

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First Name

Abd-Elrahman Atef

Last Name

Shawkat

MiddleName

-

Affiliation

Department of Cardiology - Faculty of Medicine, Al-Azhar University

Email

abdou_shawkat@hotmail.com

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Orcid

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Volume

77

Article Issue

1

Related Issue

7138

Issue Date

2019-10-01

Receive Date

2019-09-01

Publish Date

2019-10-01

Page Start

4,720

Page End

4,726

Print ISSN

1687-2002

Online ISSN

2090-7125

Link

https://ejhm.journals.ekb.eg/article_46750.html

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https://ejhm.journals.ekb.eg/service?article_code=46750

Order

8

Type

Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Assessment of Left Ventricular Function and Contractile Reserve in Patients with Hypertension

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Article

Created At

22 Jan 2023