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45934

Role of Plasma Amino Acids Profiles in Pathogenesis and Prediction of Severity in Patients with Drug Resistant Epilepsy

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Last updated: 03 Jan 2025

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Abstract

Background: Abnormal plasma levels of free amino acids may predict the severity in patients with drug resistant epilepsy (PRE), having probability to affect their therapeutic approach.
Objectives:We aimed to illuminate the effect of plasma free amino acids (PFAAs) profiles on the etiology of patients with PRE and their contribution on the frequencies of epileptic fits.
Patients and Methods:We collected clinical and metabolomic data of 90 subjects; 45 of them were PRE patients, and other 45 age and sex matched healthy controls. Quantitative measurements of PFAAs profiles using SykamAutomatic Amino Acid Analyzer S433, in addition to fasting blood sugar, liver function tests, kidney function tests and lipid profile also, were determined.
Results: The plasma levels of glutamate, glycine and Gamma amino butyric acid(GABA) plasma levels were significantly increased in PRE group compared to controls (p˂0.0001),their plasma levels also showed significant increase with increased frequency of epileptic fits. Plasma leucine, phenylalanine, aspartate ,ornithine, citrulline, serine and alanine levels (p˂0.0001) were significantly increased in PRE group in relation to healthy controls. Interestingly, on the other hand, histidine, isoleucine, lysine, threonine and the amino acid derivative taurine levels were significantly decreased in PRE patients compared to healthy controls.
Conclusion:Few biomarkers of PRE are available to find the severity and rate of progressionof PRE. The present study showed that altered plasma amino acids and their derivatives may be candidate markers for PRE, help explaining its pathogenesis, and for further researches concerning normalization of the disturbed amino acid/s or its derivative/s (GABA and taurine) in managing PRE patients.

DOI

10.21608/ejhm.2019.45934

Keywords

Aminogram, Plasma free amino acid profile, Pharmacoresistant epilepsy

Authors

First Name

Tahia H.

Last Name

Saleem

MiddleName

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Affiliation

Medical Biochemistry and Molecular biology Department, Faculty of Medicine, Assiut University,

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Orcid

-

First Name

Ahmed Y.

Last Name

Nassar

MiddleName

-

Affiliation

Medical Biochemistry and Molecular biology Department, Faculty of Medicine, Assiut University,

Email

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City

-

Orcid

-

First Name

Hamdy N

Last Name

El-Tallawy

MiddleName

-

Affiliation

Neurology and Psychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

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City

-

Orcid

-

First Name

Sara A

Last Name

Atta

MiddleName

-

Affiliation

Medical Biochemistry and Molecular biology Department, Faculty of Medicine, Assiut University,

Email

-

City

-

Orcid

-

First Name

Marwa A.

Last Name

Dahpy

MiddleName

-

Affiliation

Medical Biochemistry and Molecular biology Department, Faculty of Medicine, Assiut University,

Email

marwadahpy@aun.edu.eg

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-

Orcid

-

Volume

77

Article Issue

1

Related Issue

7138

Issue Date

2019-10-01

Receive Date

2019-08-26

Publish Date

2019-10-01

Page Start

4,681

Page End

4,687

Print ISSN

1687-2002

Online ISSN

2090-7125

Article File

EJHM_Volume 77_Issue 1_Pages 4681-4687.pdf

PDF . 672.5kB

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https://ejhm.journals.ekb.eg/article_45934.html

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https://ejhm.journals.ekb.eg/service?article_code=45934

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Original Article

Type Code

606

Publication Type

Journal

Publication Title

The Egyptian Journal of Hospital Medicine

Publication Link

https://ejhm.journals.ekb.eg/

MainTitle

Role of Plasma Amino Acids Profiles in Pathogenesis and Prediction of Severity in Patients with Drug Resistant Epilepsy

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Article

Created At

22 Jan 2023