Background: nasolabial cyst is relatively rare soft tissue lesion of nasal alar region. It is nonodontogenic in origin. Surgical sublabial excision is the treatment of choice for nasolabial cyst (NLC). However, it is associated with high complication rate. The transnasal marsupialization was introduced as an alternative modality of surgery. Aim of the work: to compare between both approaches to assess the intra-and post-operative outcome. Patients and Methods: twenty two patients presented by unilateral nasolabial cyst were included in the study and divided into two equal groups: endoscopic transnasal marsupialization (TM group; 11 patients) and sublabial surgical excision technique (SL group; 11 patients). For all patients, operative time, postoperative pain, postoperative complications and recurrence of the NLC were documented. Results: the operative time was significantly shorter in TM when compared to SL group (18.54±3.01 vs. 44.63±5.4 minutes respectively). Postoperative VAS was lower in TM when compared to SL group (3.09±0.83 vs. 6.09±1.13 respectively). The overall complications were significantly lower in TM group (18.2%) when compared to SL group (72.7%). Conclusion: the transnasal endoscopic marsupialization is preferred than conventional sublabial approach as it had shorter operative time, less postoperative pain and lower overall complications rate.